Infections

New Drug Might Solve Problem of Antibiotic Resistance

07/09/2015

Edmond J. LaVoie, PhD, Professor and Chair of the Department of Medicinal Chemistry at Rutgers University and Co-Founder of TAXIS Pharmaceuticals, discusses the potential of a new antibiotic to combat the increasing problems of antibiotic resistance. TAXIS Pharmaceuticals has identified a new agent, labeled TXA-709, that has a unique mechanism of action compared with other antibiotics that target Methicillin-resistant Staphylococcus aureus, or MRSA. TXA-709 can run interference on the process of cytokinesis, the way in which bacterial cells divide.

Rather than affecting the DNA or protein synthesis of cells, TXA-709 inhibits the activity of FtsZ, the substance responsible for recruiting the necessary materials for cell division to take place. This method of action is different from all previous antibiotic agents used in medicine. The drug is both orally and intravenously efficacious, making its mode of delivery more versatile than other drugs used to treat similar bacterial infections. Most importantly, this agent will experience little to no cross-resistance from other antibiotics, since it is the first to use this form of cellular division inhibition.

For more videos, visit our partners at The Doctor's Channel.

Related Content

Alzheimer Disease
Alzheimer Disease
Barak Gaster, MD, on Improving Dementia Care
04/14/2021
In this video, Barak Gaster, MD discusses identifying dementia and managing care in the primary care setting, a topic he is presenting at our Practical Updates in Primary Care 2021 Virtual Series on May...
04/14/2021
Chronic Obstructive Pulmonary Disease
Antonio Anzueto
Chronic Obstructive Pulmonary Disease
Antonio Anzueto, MD, on Single-Inhaler Triple Therapy Improves Lung Function In COPD
11/25/2010
In this video, Antonio Anzueto, MD, talks about the findings and clinical impacts of his team's study that compared fluticasone furoate/umeclidinium/vilanterol in a single inhaler with tiotropium among...
11/25/2010
Wound Care
Wound Care
Human Amniotic Membrane Allografts
09/10/2015
Charles M. Zelen, DPM, FACFAS, discusses some of the challenges of producing EpiFix, a leading dehydrated Human Amnion/Chorion Membrane (dHACM) allograft proven to be extremely effective at healing diabetic...
09/10/2015
Stress and Burnout
Stress and Burnout
How I Practice Now: Telehealth Tips and 5 Ways to Keep Healthy During the Pandemic
04/13/2020
In this video, Cardiology Consultant Advisory Board Member Andrew Freeman, MD, lists 5 things you should do each day to care for yourself so that you can better care for your patients. He also provides...
04/13/2020
Renal Disease
James J. Matera
Renal Disease
CRS 2015: Addressing Chronic Renal Disease in Your Practice
09/26/2015
Faculty member James J. Matera, DO, FACOI, Nephrology Hypertension Associates of Central NJ; Co-Director, Physician Integration, CentraState Medical Center; talks about what primary care clinicians can do...
09/26/2015