10/07/2019
In this podcast, S. Thomas Carmichael, MD, PhD, discusses the roles of CREB, CCR5, and tonic GABA signaling in memory formation during stroke recovery, as well as other advances in regenerative medicine from the upcoming ANA 2019 annual meeting.
Additional Resources:
- Calakos N, Carmichael ST, Sansing L, Silva AJ, Tuszynski M. Advances in regenerative medicine: cellular memory systems in brain repair. Talk presented at: American Neurology Association’s 144th Annual Meeting; October 13-15, 2019: St. Louis, MO. https://2019.myana.org/program/sessions/advances-regenerative-medicine-cellular-memory-systems-brain-repair.
- Caracciolo L, Marosi M, Mazzitelli J, et al. CREB controls cortical circuit plasticity and functional recovery after stroke. Nature Comm. 2018;9(1):2250. https://doi.org/10.1038/s41467-018-04445-9.
- Clarkson AN, Huang BS, Macisaac SE, Mody I, Carmichael ST. Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke. Nature. 2010;468(7321):305-309. https://doi.org/10.1038/nature09511.
- Joy MT, Ben Assayag E, Shabashov-Stone D, et al. CCR5 is a therapeutic target for recovery after stroke and traumatic brain injury. Cell. 2019;176(5):1143-1157.e13. https://doi.org/10.1016/j.cell.2019.01.044.
- Zhou M, Greenhill S, Huang S, Silva AJ, et al. CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory. Elife. 2016;5. pii: e20985. https://doi.org/10.7554/eLife.20985.
S. Thomas Carmichael, MD, PhD, is the chair of the Neurology Department and a professor of neurology at UCLA David Geffon School of Medicine in Los Angeles, California. He is also the co-director of UCLA Broad Stem Cell Research Center.