Diastolic Dysfunction Linked to Albuminuria in Patients with Type 2 Diabetes

Worsening albuminuria status was associated with diastolic dysfunction and cardiac remodeling in patients with type 2 diabetes, according to a recent study.

The study included 915 patients with type 2 diabetes who were stratified according to their albuminuria status as either normoalbuminuria, microalbuminuria, or macroalbuminuria. Patients underwent a comprehensive echocardiography, which included conventional imaging, issue Doppler imaging, and 2D speckle tracking.
____________________________________________________________________
RELATED CONTENT
HF in Diabetes: Long-Term Prognosis has Improved
Twice-Daily Aspirin Is Cardio-Protective for Diabetes Patients Without CVD
Diabetes Treatment Improves Risks of All Cause, CV Mortality
____________________________________________________________________

Overall, cardiac remodeling was associated with increased albuminuria severity in patients with increases in left ventricular (LV) mass index and LV wall thickness.

While worsening diastolic measures were associated with albuminuria severity and left atrial volume index, only patients with macroalbuminuria experienced worsening systolic measures.

Additional subgroup analyses of patients without known coronary heart disease and with normal ejection fraction showed similar results.

“In patients with type 2 diabetes, microalbuminuria is associated with decreased diastolic function whereas decreased systolic function was only associated with macroalbuminuria supporting the notion of similar pathogenic mechanisms of albuminuria and impaired myocardial function.”

—Melissa Weiss

Reference:

Jørgensen PG, Biering-Sørensen T, Mogelvang R, et al. Presence of micro- and macroalbuminuria and the association with cardiac mechanics in patients with type 2 diabetes [published online before print October 3, 2017]. Eur Heart J Cardiovasc Imaging. doi: 10.1093/ehjci/jex231.