Could Testosterone Replacement Therapy Improve Ejaculatory Dysfunction?

Testosterone replacement therapy does not improve ejaculatory dysfunction in men androgen-deficient men, according to a recent study.

“Low testosterone levels have been associated with ejaculatory dysfunction (EjD) in cross-sectional studies; however, the efficacy of testosterone replacement in improving EjD has not been studied in a randomized controlled trial,” said the study’s authors.
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For their study, researchers evaluated 66 men who displayed 1 or more symptoms of EjD—including decreased ejaculate volume or reduced force of ejaculation, anejaculation, and delayed ejaculation—and had 2 overall testosterone level measurements that were <300 ng/dL.

For 16 weeks, participants were given either 60 mg of 2% testosterone solution or placebo.

Overall, while testosterone treatment improved scores on the Male Sexual Health Questionnaire-Ejaculatory Dysfunction-Short Form, the results were not statistically significant when compared with placebo.

The complete study published in the July issue of the Journal of Clinical Endocrinology and Metabolism.

-Michelle Canales Butcher

Reference:

Paduch DA, Polzer PK, Ni X, Basaria S. Testosterone replacement in androgen-deficient men with ejaculatory dysfunction: a randomized controlled trial. J Clin Endocrinol Metab. 2015 July [epub ahead of print] doi: http://dx.doi.org/10.1210/jc.2014-4434.