Is Aspirin Effective for Primary Prevention in HF, Diabetes Patients?
Primary prevention with aspirin is associated with a lower risk of mortality but a higher risk of non-fatal myocardial infarction (MI) and among patients with type 2 diabetes and heart failure, a new study showed.
Findings from the study will be presented at the American College of Cardiology 2018 67th Annual Scientific Session and Expo, which will take place from March 10 to 12 in Orlando, Florida.
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For their study, the researches assessed 12,534 patients with HF and type 2 diabetes. Data were obtained from The Health Improvement Network (THIN) UK primary care database. Follow-up lasted 5.2 years.
The role of treatment with more than 75 mg aspirin was investigated, and outcomes following an HF diagnosis were compared for aspirin-treated (n = 5967) and non-aspirin-treated patients (n = 6567).
Following adjustment, results showed that that aspirin use was significantly associated with reduced all-cause mortality and HF hospitalization in this cohort (hazard ratio 0.89). However, aspirin use was also found to be associated with an increase in non-fatal MI and stroke.
The researchers noted that aspirin use did not impact the risk of major bleeding, and that a dose of more than 75 mg provided no additional benefit.
“Primary prevention with aspirin in patients with T2D and HF lowers mortality, but increases non-fatal MI/stroke,” the researchers concluded.
—Christina Vogt
Reference:
Khalil CA, Omar O, Al Suwaidi J, Taheri S. Primary prevention with aspirin reduces mortality in type 2 diabetes and heart failure: results from the THIN Primary Care Database. Paper presented at: ACC.18 67th Annual Scientific Session & Expo; March 11, 2018; Orlando, FL. http://www.abstractsonline.com/pp8/ - !/4496/presentation/40224.